Bone Abstracts

Introduction: Wnt ligands bind to LDL receptor-related protein (LRP) 5 or −6, triggering a cascade of downstream events that include β-catenin signaling. Here, we explored the roles of LRP5 in interleukin (IL)-1β- or Wnt-mediated osteoarthritic (OA) cartilage destruction in mice.Methods: The expression levels of LRP5, Type II collagen, and catabolic factors were determined in mouse articular chondrocytes, human OA cartilage, and mouse exp...